Prostate cancer is the most common cancer among men with approximately 220800 new occurrences in the united states in 2015 1 approximately 12 of patients have lymph node metastasis at diagnosis 2 although node positive disease is technically classified as stage iv it is distinct from distant metastatic prostate cancer in that a . Case 1 the prostate itself has not yet been treated when and how should possibly affected lymph nodes be treated or removed the radical surgical removal of the lymph nodes also called lymphadenectomy is still a standard method in prostate cancer. The presence of lymph node involvement lni represents one of the most relevant prognostic factors in prostate cancer pca patients where individuals with lni exhibit an unfavorable natural . 5 boorjian sa thompson rh siddiqui s et al long term outcome after radical prostatectomy for patients with lymph node positive prostate cancer in the prostate specific antigen era j urol . Detection of lymph node metastases indicates poor prognosis for prostate cancer patients therefore elucidation of the mechanisms of lymph node metastasis is important to understand the progression of prostate cancer and also to develop therapeutic interventions
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